Svitlana Zubchenko
Danylo Halytsky Lviv National Medical University, Ukraine
Biography
Svitlana Zubchenko has completed his PhD from of Danylo Halytsky Lviv National Medical University and Postdoctoral studies from of Danylo Halytsky Lviv National Medical University. She is the Regular Member of EEACI. She has published more than 50 papers in reputed journals and has been serving as an Editorial Board Member of repute.
Abstract
Resume: Among the infectious agents with a characteristic life-long persistence in the human body is the Epstein-Barr virus (EBV). With poor quality or reduced immune response, chronic EBV infection is activated and becomes a trigger of various pathological disorders.
Aim: To investigate the clinical and laboratory features of patients with allergic pathology on the background of chronic EBV infection in the activation phase.
Materials & Methods: We examined 62 patients of 28.6±2.4 years age, 53.3% females and 46.7% males. General clinical, laboratory, instrumental, cytological tests, molecular genetics, SPT, sIgE to EBV were measure and compared.
Results: The verification of allergic pathology was carried out according to the following clinical features: 51 (82.25%) periodic rhinorrhoea, 50 (80.64%) - nasal congestion, 34 (54.83%) - rhinoconjunctivitis, 45 (72.58%) - pruritus of the nose/eyes, 55 (88.70%) - periodic sneezing, 11 (17.74%) - cough and shortness of breath, 19 (30.64%) - erythematous and squamous rashes on the skin with itching. Patients were diagnosed with intermittent allergic rhinitis (AR) - 32.26%; persistent AR - 45.16%; atopic dermatitis (AD) - 22.58%. Among them, 51.62% had EBV infection at latent stage (group 1), 48.38% - EBV infection in the active stage (2nd group). The patients in the 2nd group showed more often skin irritation and itching, genetic predisposition to allergic diseases, polysensitization (p<0.05), sensitization to spring trees (53.33%) and HDM (66.37%). The number of patients with hyper-IgE syndrome was the same (50.00%) in two groups, and the intensity of synthesis of total IgE in serum was significantly higher in patients with active EBV infection (p<0.05).
Conclusions: In 48.38% of patients with allergic diseases was detected a chronic EBV infection in the active stage (DNA EBV “+”). The results of studies confirm the influence of active EBV infection to the course of allergic diseases in adults, pointing to the relevance and perspective of this area of research.